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ethylmalonyl-CoA pathway

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(3S)-3-carboxy-3-hydroxypropanoyl-CoA <=> glyoxylate + acetyl-CoA 4.1.3.24 malyl-CoA lyase
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(S)-malate + CoA + ATP <=> phosphate + (3S)-3-carboxy-3-hydroxypropanoyl-CoA + ADP 6.2.1.5 succinate---CoA ligase (ADP-forming)
6.2.1.9 malate---CoA ligase
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beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O 4.2.1.148 2-methylfumaryl-CoA hydratase
4.2.1.153 3-methylfumaryl-CoA hydratase
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(2S)-methylsuccinyl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> 2-methylfumaryl-CoA + reduced_flavodoxin 1.3.8.12 (2S)-methylsuccinyl-CoA dehydrogenase
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(2S)-ethylmalonyl-CoA + NADP+ <=> crotonyl-CoA + CO2 + NADPH 1.3.1.85 crotonyl-CoA carboxylase/reductase
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(2R)-ethylmalonyl-CoA <=> (2S)-methylsuccinyl-CoA 5.4.99.63 ethylmalonyl-CoA mutase
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(3R)-hydroxybutyryl-CoA + NADP+ <=> acetoacetyl-CoA + NADPH + H+ 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
1.1.1.157 3-hydroxybutyryl-CoA dehydrogenase
1.1.1.36 acetoacetyl-CoA reductase
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–
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beta-methylmalyl-CoA <=> glyoxylate + propionyl-CoA 4.1.3.24 malyl-CoA lyase
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(3R)-hydroxybutyryl-CoA <=> crotonyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase
4.2.1.55 3-hydroxybutyryl-CoA dehydratase
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
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(2S)-ethylmalonyl-CoA <=> (2R)-ethylmalonyl-CoA 5.1.99.1 methylmalonyl-CoA epimerase
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acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase
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Visualization of the pathway